Zusammenfassung
The reaction of tetracycline with K2PtCl4 in glacial acetic acid leads to the dehydration of tetracycline to anhydrotetracycline (ahtc) which coordinates as a bidentate ligand to the PtCl2 moiety. The composition of Pt(ahtc)Cl-2 is confirmed by elemental analysis and mass spectrometry. On the basis of the electronic spectra it is suggested that the coordination takes place at the A ring of ahtc ...
Zusammenfassung
The reaction of tetracycline with K2PtCl4 in glacial acetic acid leads to the dehydration of tetracycline to anhydrotetracycline (ahtc) which coordinates as a bidentate ligand to the PtCl2 moiety. The composition of Pt(ahtc)Cl-2 is confirmed by elemental analysis and mass spectrometry. On the basis of the electronic spectra it is suggested that the coordination takes place at the A ring of ahtc while the BCD ring system is preserved as separate chromophore. It is characterized by a long-wavelength absorption and fluorescence which appear at lambda(max) = 428 and 550 nm, respectively, for the free ahtc ligand and lambda(max) = 425 and 550 nm for Pt(ahtc)Cl-2. (C) 2002 Elsevier Science B.V. All rights reserved.
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