Zusammenfassung
A series of bidentate and tridentate (S)-NOBIN derivatives was synthesised and tested as chiral ligands in the Ru-catalysed enantioselective transfer hydrogenation of acetophenone with 2-propanol. Despite the similarities in chemical structure, only the imine derived from (S)-NOBIN and 2-pyridinecarbaldehyde and the corresponding amine (obtained by NaBH4 reduction of the imine) afforded ...
Zusammenfassung
A series of bidentate and tridentate (S)-NOBIN derivatives was synthesised and tested as chiral ligands in the Ru-catalysed enantioselective transfer hydrogenation of acetophenone with 2-propanol. Despite the similarities in chemical structure, only the imine derived from (S)-NOBIN and 2-pyridinecarbaldehyde and the corresponding amine (obtained by NaBH4 reduction of the imine) afforded (S)-l-phenylethanol in nearly quantitative yields and outstanding enantioselectivities of up to 97% e.e. (C) 2002 Elsevier Science Ltd. All rights reserved.
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