ZAAK, DIRK ; FRIMBERGER, DOMINIC ; STEPP, HERBERT ; WAGNER, SIMON ; BAUMGARTNER, REINHOLD ; SCHNEEDE, PETER ; SIEBELS, MICHAEL ; KNÜCHEL, RUTH ; KRIEGMAIR, MARTIN ; HOFSTETTER, ALFONS
Alternative Links zum Volltext:DOIVerlag
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | Journal of Urology |
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| Verlag: | LIPPINCOTT WILLIAMS & WILKINS |
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| Ort der Veröffentlichung: | PHILADELPHIA |
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| Band: | 166 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 5 |
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| Seitenbereich: | S. 1665-1669 |
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| Datum: | 2001 |
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| Institutionen: | Medizin > Lehrstuhl für Pathologie |
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| Identifikationsnummer: | | Wert | Typ |
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| 10.1016/S0022-5347(05)65649-2 | DOI |
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| Stichwörter / Keywords: | TRANSITIONAL-CELL CARCINOMA; PROTOPORPHYRIN-IX; TRANSURETHRAL RESECTION; PHOTODYNAMIC THERAPY; ENDOSCOPY; DIAGNOSIS; TUMORS; bladder; bladder neoplasms; carcinoma; transitional cell; aminolevulinic acid; fluorescence |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Dokumenten-ID: | 73372 |
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Web of Science
Zusammenfassung
Purpose: 5-Aminolevulinic acid induced fluorescence endoscopy has outstanding sensitivity for detecting early stage bladder cancer. Nevertheless, a third of the lesions that show specific fluorescence are histologically benign. We decreased the false-positive rate of 5-aminolevulinic acid induced fluorescence endoscopy by incorporating protoporphyrin IX fluorescence quantification into the ...
Zusammenfassung
Purpose: 5-Aminolevulinic acid induced fluorescence endoscopy has outstanding sensitivity for detecting early stage bladder cancer. Nevertheless, a third of the lesions that show specific fluorescence are histologically benign. We decreased the false-positive rate of 5-aminolevulinic acid induced fluorescence endoscopy by incorporating protoporphyrin IX fluorescence quantification into the standard cystoscopy procedure. Materials and Methods: In 25 cases (53 biopsies) of a history of or suspicion for bladder cancer 5-aminolevulinic acid induced fluorescence endoscopy and fluorescence image quantification were performed. For fluorescence image quantification images obtained with a target integrating color charge-coupled device camera were digitized and stored in a personal computer. Red-to-blue ratios were calculated from fluorescence positive lesions and results were correlated with hematoxylin and eosin histology. Results: Malignant fluorescence positive lesions showed significantly stronger fluorescence intensity than fluorescing lesions with benign histology. A threshold was established that decreased the false-positive rate by 30% without affecting sensitivity. Conclusions: Fluorescence image quantification is a new endoscopic method for objectively selecting multicolor fluorescence bladder lesion images for biopsy. It has the potential of eliminating human error by different surgeons with variable experience in fluorescence endoscopy.
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