Alternative Links zum Volltext:DOIVerlag
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | Frontiers in Bioscience |
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| Verlag: | FRONTIERS IN BIOSCIENCE INC |
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| Ort der Veröffentlichung: | MANHASSET |
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| Band: | 6 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 1 |
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| Seitenbereich: | d505 |
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| Datum: | 2001 |
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| Institutionen: | Medizin > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
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| Identifikationsnummer: | | Wert | Typ |
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| 10.2741/Schmitz | DOI |
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| Stichwörter / Keywords: | BINDING CASSETTE TRANSPORTER-1; MULTIDRUG-RESISTANCE PROTEIN; DISEASE GENE ABCR; FAMILIAL INTRAHEPATIC CHOLESTASIS; CAUSE PSEUDOXANTHOMA ELASTICUM; DUBIN-JOHNSON-SYNDROME; CONJUGATE EXPORT PUMP; MDR1 P-GLYCOPROTEIN; MAP KINASE CASCADE; RECEPTOR LXR-ALPHA; ABC transporter; ABCA1; macrophage; lipid; cholesterol; phospholipids; caveolin; NPC1; review |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Dokumenten-ID: | 73791 |
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Web of Science
Zusammenfassung
ATP-binding cassette (ABC) proteins form a group of highly conserved cellular transmembrane transporters. Studies over the past year have implicated ABC transporters in cellular lipid trafficking processes. This notion has recently been confirmed and extended by the finding that the ABC transporter ABCA1 is a key regulator of high-density lipoprotein (HDL) metabolism and macrophage targeting to ...
Zusammenfassung
ATP-binding cassette (ABC) proteins form a group of highly conserved cellular transmembrane transporters. Studies over the past year have implicated ABC transporters in cellular lipid trafficking processes. This notion has recently been confirmed and extended by the finding that the ABC transporter ABCA1 is a key regulator of high-density lipoprotein (HDL) metabolism and macrophage targeting to the RES or the vascular wall. Expression of a large number of ABC transporters in monocytes/macrophages and their regulation by cholesterol flux render these transporter molecules potentially critical players in chronic inflammatory diseases such as atherosclerosis.
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