Zusammenfassung
The antimicrobial activity of linezolid, a recently developed antibiotic agent active against Gram-positive bacteria, was tested against pathogens from three different collections. (1) Uropathogens from hospitalized urological patients (1990/1991) with complicated and/or hospital-acquired UTls, Urologic Clinic, Hospital St. Elisabeth, Straubing. (2) Uropathogens from a multi-centre study ...
Zusammenfassung
The antimicrobial activity of linezolid, a recently developed antibiotic agent active against Gram-positive bacteria, was tested against pathogens from three different collections. (1) Uropathogens from hospitalized urological patients (1990/1991) with complicated and/or hospital-acquired UTls, Urologic Clinic, Hospital St. Elisabeth, Straubing. (2) Uropathogens from a multi-centre study (1995/1996) comprising 37 urological centres throughout Germany. (3) MRSA isolates of patients and staff (1999/2000) within the Hospital St. Elisabeth, Straubing. Genotyping of the latter isolates was performed by pulsed-field-electrophoresis. The minimal inhibitory concentrations (MIC) of linezolid determined by an agar (Isosensitest) dilution method using a multipoint inoculator and an inoculum of 10(4) cfu per point ranged for methicillin susceptible Staphylococcus aureus (MSSA) (n = 27) between 2 and 4 mg/l, for methicillin resistant S. aureus (MRSA) (n = 35) between I and 2 mg/l, for methicillin susceptible coagulase-negative staphylococci (CNS) (MSSE) (n = 67) between 0.5 and 4 mg/l, for methicillin resistant CNS (MRSE) (n = 19) between 0.25 and 2 mg/l, for Enterococcus. faecalis (n = 184) between 0.5 and 4 mg/l, for E. faecium (it = 3) 2 mg/l and for Streptococcus spp. (n = 4) between 0.25 and I mg/l, indicating that all strains were susceptible. According to the in vitro activity, linezolid may be considered a promising antibacterial agent for the treatment of complicated UTI caused by Gram-positive uropathogens. Thus, linezolid should be evaluated in a clinical study. (C) 2001 Elsevier Science BN. and International Society of Chemotherapy. All rights reserved.
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