This Special Issue of the Journal of Personalized Medicine presents extended versions of selected contributions to pHealth 2022, the 19th International Conference on Wearable Micro and Nano Technologies for Personalized Health, held on 8–10 November 2022 in Oslo, Norway. The original papers were published in the IOS Press Studies in Health Technology and Informatics 2022, volume 299 (URL https://ebooks.iospress.nl/volume/phealth-2022-proceedings-of-the-19th-international-conference-on-wearable-micro-and-nano-technologies-for-personalized-health-810-november-2022-oslo-norway (accessed on 3 November 2022)).