Evaluation of the need for dosing adaptations in obese patients for surgical antibiotic prophylaxis: a model-based analysis of cefazolin pharmacokinetics

URN to cite this document:: urn:nbn:de:bvb:355-epub-748241
DOI to cite this document:: 10.5283/epub.74824

Bindellini, Davide ; Simon, Philipp ; Busse, David ; Michelet, Robin ; Petroff, David ; Aulin, Linda B. S. ; Dorn, Christoph

; Zeitlinger, Markus ; Huisinga, Wilhelm ; Wrigge, Hermann ; Kloft, Charlotte

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 04 Feb 2025 07:06

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Abstract

Background: Cefazolin is used as a prophylactic antibiotic to reduce surgical site infections (SSIs). Obesity has been identified as a risk factor for SSIs. Cefazolin dosing recommendations and guidelines are currently inconsistent for obese patients. As plasma and target-site exposure might differ, pharmacokinetic data from the sites of SSIs are essential to evaluate treatment efficacy: these ...