Laryngectomy plus postoperative radio(system)therapy versus primary radio(system) therapy for the treatment of locally advanced laryngeal and hypopharyngeal cancer – results from the University Clinical Cancer Registry Regensburg

URN zum Zitieren dieses Dokuments:

urn:nbn:de:bvb:355-epub-748672 Copy

DOI zum Zitieren dieses Dokuments:

10.5283/epub.74867 Copy

Maurer, Julia ; Kuenzel, Julian ; Bohr, Christopher ; Koelbl, Oliver ; Mueller, Karolina ; Koller, Michael ; Concato, Oreste-Konrad ; Vielsmeier, Veronika ; Suess, Christoph

Veröffentlichungsdatum dieses Volltextes: 05 Feb 2025 13:29

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Alternative Links zum Volltext:DOIVerlag

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Details

Dokumentenart:	Artikel
Open Access Art:	Kein Open Access
Titel eines Journals oder einer Zeitschrift:	Acta Oto-Laryngologica
Verlag:	Taylor and Francis
Band:	144
Nummer des Zeitschriftenheftes oder des Kapitels:	3
Seitenbereich:	S. 255-262
Datum:	25 April 2024
Institutionen:	Nicht ausgewählt
Identifikationsnummer:	Wert Typ 10.1080/00016489.2024.2340086 DOI
Stichwörter / Keywords:	Hypopharygeal/laryngeal cancer, laryngectomy, primary radio(system)therapy, overall survival, recommended therapy
Dewey-Dezimal-Klassifikation:	600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin
Status:	Veröffentlicht
Begutachtet:	Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:	Ja
Dokumenten-ID:	74867

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Zusammenfassung

Background There are few adequate randomized clinical trials directly comparing the therapeutic options of primary laryngectomy (pLE) vs. primary radio(system)therapy (pR(S)T) in patients with locally advanced laryngeal and hypopharyngeal carcinoma and thus little clear scientific evidence to decide which patients will benefit most from which procedure. Aims/Objectives Aim was to compare ...

Zusammenfassung

Background

There are few adequate randomized clinical trials directly comparing the therapeutic options of primary laryngectomy (pLE) vs. primary radio(system)therapy (pR(S)T) in patients with locally advanced laryngeal and hypopharyngeal carcinoma and thus little clear scientific evidence to decide which patients will benefit most from which procedure.
Aims/Objectives

Aim was to compare survival between the therapeutic options and to learn from the limitations of this study, especially in the context of improved clinical assessment.
Material and Methods

The clinical data of patients treated between January 2010 and February 2022 were obtained from the electronic database of the University Hospital Regensburg. Overall survival (OS) and progression-free survival (PFS) were compared between the treatment groups.
Results

The study included 193 patients (pLE n = 68, pR(S)T, n = 125). Median OS was 31.2 months and median PFS was 24.7 months with no significant difference between the treatment groups (p > .050). Patients who did not receive complete treatment as recommended by the tumor conference (n = 47, 24.4%) had a higher risk of death (p = .024).
Conclusions and Significance

The results of our study are consistent with the survival data reported in the literature. More detailed systematic data in clinical routine (e.g. relevant comorbidities) are required to ensure guideline-based recommended therapy.

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Metadaten zuletzt geändert: 28 Mai 2025 17:06

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