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- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-750326
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.75032
Zusammenfassung
The nonreceptor tyrosine phosphatase SHP2 has been at the center of cell signaling research for three decades. SHP2 is required to fully activate the RTK/RAS/ERK signaling cascade, although the underlying mechanisms are not completely understood. PTPN11, which encodes SHP2, is the first identified proto-oncogene that encodes a tyrosine phosphatase, with dominantly activating mutations detected in ...
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