Interspecies differences in Plasma Protein Binding of Beta-Lactam Antibiotics

URN to cite this document:: urn:nbn:de:bvb:355-epub-750681
DOI to cite this document:: 10.5283/epub.75068

Ahmed, Hifza ; Dorn, Christoph

; Zeitlinger, Markus

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 26 Feb 2025 12:11

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Abstract

Background: Plasma protein binding (PPB) is a critical factor in drug therapy and understanding free compound exposure across preclinical and clinical species is vital for developing new antibiotics. Optimizing beta-lactam dosing based on unbound drug concentrations has garnered significant interest, yet comprehensive data on how inter-species differences in protein binding affect the ...