Simultaneous determination of ceftazidime and avibactam in patients by isocratic ion-pair liquid chromatography with photometric detection

URN to cite this document:: urn:nbn:de:bvb:355-epub-752521
DOI to cite this document:: 10.5283/epub.75252

Lier, Constantin ; Kees, Frieder

; Witowski, Andrea ; Rahmel, Tim ; Pockes, Steffen

; Dorn, Christoph

License: Creative Commons Attribution 4.0
PDF - Published Version
(817kB)

Date of publication of this fulltext: 20 Mar 2025 11:35

Alternative links to fulltext:DOI Publisher

Details

Preview

Export bibliographical data

Abstract

A simple and fast HPLC-UV method is described for the simultaneous determination of total or free ceftazidime and avibactam in serum, which is suitable for therapeutic drug monitoring (TDM) or pharmacokinetic studies in man. Sufficient retention of the very polar avibactam was obtained by addition of tetrabutylammonium hydrogen sulfate (TBA) as ion pairing agent, thus allowing the determination ...