Gleich, Otto ; Strutz, J. ; Schmid, K.
Alternative Links zum Volltext:PubmedDOI
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | HNO |
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| Verlag: | SPRINGER |
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| Ort der Veröffentlichung: | NEW YORK |
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| Band: | 56 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 12 |
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| Seitenbereich: | S. 1243-52 |
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| Datum: | 2008 |
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| Institutionen: | Medizin > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde |
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| Identifikationsnummer: | | Wert | Typ |
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| 19020845 | PubMed-ID | | 10.1007/s00106-008-1841-8 | DOI |
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| Klassifikation: | | Notation | Art |
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| Animals | MESH | | Endolymph | MESH | | Homeostasis | MESH | | Humans | MESH | | Meniere Disease/diagnosis | MESH | | Models, Biological | MESH |
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| Stichwörter / Keywords: | STRIA VASCULARIS; INNER-EAR; GUINEA-PIGS; LONG-TERM; FOLLOW-UP; GENTAMICIN; CELLS; THERAPY; MEMBRANE; Meniere's disease; Endolymph; Stria vascularis; K+ resorption and secretion; Gentamicin therapy |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Dokumenten-ID: | 7544 |
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Web of Science
Zusammenfassung
Although low dose intratympanal gentamicin has empirically been very effective in treating Meniere's disease, the mechanisms of elimination or amelioration of vertigo are still insufficiently understood. Most animal studies investigating the effect of aminoglycosides used high doses that damage or kill hair cells and many other cell types of the inner ear. Additional studies are needed to ...
Zusammenfassung
Although low dose intratympanal gentamicin has empirically been very effective in treating Meniere's disease, the mechanisms of elimination or amelioration of vertigo are still insufficiently understood. Most animal studies investigating the effect of aminoglycosides used high doses that damage or kill hair cells and many other cell types of the inner ear. Additional studies are needed to investigate the effects of low dose gentamicin to elucidate the mechanisms affecting vertigo. In this article it will be explained how disturbances of endolymph homeostasis lead to endolymphatic hydrops and finally to leakage of K+ from the endolymph into the perilymphatic space. This can lead to a non-physiological activation of vestibular nerve fibres thus causing vertigo.
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