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Ectoenzymes as promising cell identification structures for the high avidity targeting of polymeric nanoparticles

Walter, Melanie ; Baumann, Felix ; Schorr, Kathrin ; Goepferich, Achim



Zusammenfassung

Pharmacotherapy is often limited by undesired side effects while insufficient drug reaches the site of action. Active-targeted nanotherapy should provide a solution for this problem, by using ligands in the nanoparticle corona for the identification of receptors on the target-cell surface. However, since receptor binding is directly associated with pharmacological responses, today's targeting ...

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