A Bayesian multi‐arm multi‐stage clinical trial design incorporating information about treatment ordering

URN to cite this document:: urn:nbn:de:bvb:355-epub-756767
DOI to cite this document:: 10.5283/epub.75676

Serra, Alessandra

; Mozgunov, Pavel ; Jaki, Thomas

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 18 Mar 2025 10:03

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Abstract

Multi-Arm Multi-Stage (MAMS) designs can notably improve efficiency in later stages of drug development, but they can be suboptimal when an order in the effects of the arms can be assumed. In this work, we propose a Bayesian multi-arm multi-stage trial design that selects all promising treatments with high probability and can efficiently incorporate information about the order in the treatment ...