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From Hair to the Brain: The Short-Term Therapeutic Potential of Human Hair Follicle-Derived Stem Cells and Their Conditioned Medium in a Rat Model of Stroke

Karimi-Haghighi, Saeideh ; Pandamooz, Sareh ; Jurek, Benjamin ; Fattahi, Sadegh ; Safari, Anahid ; Azarpira, Negar ; Dianatpour, Mehdi ; Hooshmandi, Etrat ; Bayat, Mahnaz ; Owjfard, Maryam ; Zafarmand, Seyedeh Shaghayegh ; Mostaghel, Mandana ; Mousavi, Seyedeh Maryam ; Jashire Nezhad, Nahid ; Eraghi, Vida ; Fadakar, Nima ; Rahimi Jaberi, Abbas ; Garcia-Esperon, Carlos ; Spratt, Neil ; Levi, Christopher ; Salehi, Mohammad Saied ; Borhani-Haghighi, Afshin



Abstract

The short-term therapeutic impacts of stem cells and their derivatives were frequently reported in preclinical investigations of ischemic stroke (IS); however, several drawbacks including accessibility, abundancy, and ethical concerns limited their clinical application. We describe here for the first time the therapeutic potential of human hair follicle-derived stem cells (hHFSCs) and their ...

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