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Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies

Finze, Anika ; Biechele, Gloria ; Rauchmann, Boris-Stephan ; Franzmeier, Nicolai ; Palleis, Carla ; Katzdobler, Sabrina ; Weidinger, Endy ; Guersel, Selim ; Schuster, Sebastian ; Harris, Stefanie ; Schmitt, Julia ; Beyer, Leonie ; Gnörich, Johannes ; Lindner, Simon ; Albert, Nathalie L. ; Wetzel, Christian H. ; Rupprecht, Rainer ; Rominger, Axel ; Danek, Adrian ; Burow, Lena ; Kurz, Carolin ; Tato, Maia ; Utecht, Julia ; Papazov, Boris ; Zaganjori, Mirlind ; Trappmann, Lena-Katharina ; Goldhardt, Oliver ; Grimmer, Timo ; Haeckert, Jan ; Janowitz, Daniel ; Buerger, Katharina ; Keeser, Daniel ; Stoecklein, Sophia ; Dietrich, Olaf ; Morenas-Rodriguez, Estrella ; Barthel, Henryk ; Sabri, Osama ; Bartenstein, Peter ; Simons, Mikael ; Haass, Christian ; Höglinger, Günter U. ; Levin, Johannes ; Perneczky, Robert ; Brendel, Matthias



Abstract

& beta;-amyloid (A & beta;) and tau aggregation as well as neuronal injury and atrophy (ATN) are the major hallmarks of Alzheimer's disease (AD), and biomarkers for these hallmarks have been linked to neuroinflammation. However, the detailed regional associations of these biomarkers with microglial activation in individual patients remain to be elucidated. We investigated a cohort of 55 patients ...

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