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Assessment of Predictive Genomic Biomarkers for Response to Cisplatin-based Neoadjuvant Chemotherapy in Bladder Cancer

Gil-Jimenez, Alberto ; van Dorp, Jeroen ; Contreras-Sanz, Alberto ; van der Vos, Kristan ; Vis, Daniel J. ; Braaf, Linde ; Broeks, Annegien ; Kerkhoven, Ron ; van Kessel, Kim E.M. ; Ribal, María José ; Alcaraz, Antonio ; Wessels, Lodewyk F.A. ; Seiler, Roland ; Wright, Jonathan L. ; Mengual, Lourdes ; Boormans, Joost ; van Rhijn, Bas W.G. ; Black, Peter C. ; van der Heijden, Michiel S.



Zusammenfassung

Cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy is rec-ommended for patients with muscle-invasive bladder cancer (MIBC). It has been shown that somatic deleterious mutations in ERCC2, gain-of-function mutations in ERBB2, and alterations in ATM, RB1, and FANCC are correlated with pathological response to NAC in MIBC. The objective of this study was to validate these ...

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