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A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy

Stein-Thoeringer, Christoph K. ; Saini, Neeraj Y. ; Zamir, Eli ; Blumenberg, Viktoria ; Schubert, Maria-Luisa ; Mor, Uria ; Fante, Matthias A. ; Schmidt, Sabine ; Hayase, Eiko ; Hayase, Tomo ; Rohrbach, Roman ; Chang, Chia-Chi ; McDaniel, Lauren ; Flores, Ivonne ; Gaiser, Rogier ; Edinger, Matthias ; Wolff, Daniel ; Heidenreich, Martin ; Strati, Paolo ; Nair, Ranjit ; Chihara, Dai ; Fayad, Luis E. ; Ahmed, Sairah ; Iyer, Swaminathan P. ; Steiner, Raphael E. ; Jain, Preetesh ; Nastoupil, Loretta J. ; Westin, Jason ; Arora, Reetakshi ; Wang, Michael L. ; Turner, Joel ; Menges, Meghan ; Hidalgo-Vargas, Melanie ; Reid, Kayla ; Dreger, Peter ; Schmitt, Anita ; Müller-Tidow, Carsten ; Locke, Frederick L. ; Davila, Marco L. ; Champlin, Richard E. ; Flowers, Christopher R. ; Shpall, Elizabeth J. ; Poeck, Hendrik ; Neelapu, Sattva S. ; Schmitt, Michael ; Subklewe, Marion ; Jain, Michael D. ; Jenq, Robert R. ; Elinav, Eran



Zusammenfassung

Conserved microbiome features across clinical and geographical variations may enable microbiome-based predictions of outcomes in CD19-targeted CAR-T cell immunotherapy Increasing evidence suggests that the gut microbiome may modulate the efficacy of cancer immunotherapy. In a B cell lymphoma patient cohort from five centers in Germany and the United States (Germany, n = 66; United States, n = ...

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