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M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer’s patch

Torow, Natalia ; Li, Ronghui ; Hitch, Thomas Charles Adrian ; Mingels, Clemens ; Al Bounny, Shahed ; van Best, Niels ; Stange, Eva-Lena ; Simons, Britta ; Maié, Tiago ; Rüttger, Lennart ; Gubbi, Narasimha Murthy Keshava Prasad ; Abbott, Darryl Adelaide ; Benabid, Adam ; Gadermayr, Michael ; Runge, Solveig ; Treichel, Nicole ; Merhof, Dorit ; Rosshart, Stephan Patrick ; Jehmlich, Nico ; Hand, Timothy Wesley ; von Bergen, Martin ; Heymann, Felix ; Pabst, Oliver ; Clavel, Thomas ; Tacke, Frank ; Lelouard, Hugues ; Costa, Ivan Gesteira ; Hornef, Mathias Walter



Abstract

Early-life immune development is critical to long-term host health. However, the mechanisms that determine the pace of postnatal immune maturation are not fully resolved. Here, we analyzed mononuclear phagocytes (MNPs) in small intestinal Peyer's patches (PPs), the primary inductive site of intestinal immunity. Conventional type 1 and 2 dendritic cells (cDC1 and cDC2) and RORgt+ ...

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