; Swol, Justyna
; Wiedemann, Dominik ; Belliato, Mirko ; Broman, Lars Mikael ; Vuylsteke, Alain ; Kassif, Yigal ; Scandroglio, Anna Mara ; Fanelli, Vito ; Gaudard, Philippe ; Ledot, Stephane ; Barker, Julian ; Boeken, Udo ; Maier, Sven ; Kersten, Alexander ; Meyns, Bart ; Pozzi, Matteo ; Pedersen, Finn M ; Schellongowski, Peter ; Kirali, Kaan ; Barrett, Nicholas ; Riera, Jordi ; Mueller, Thomas ; Belohlavek, Jan ; Lorusso, Roberto ; De Piero, Maria Elena ; Mariani, Silvia ; Di Mauro, Michele ; Folliguet, Thierry ; Taccone, Fabio Silvio ; Camporota, Luigi ; Swol, Justyna ; Wiedemann, Dominik ; Belliato, Mirko ; Broman, Lars Mikael ; Vuylsteke, Alain ; Kassif, Yigal ; Scandroglio, Anna Mara ; Fanelli, Vito ; Gaudard, Philippe ; Ledot, Stephane ; Barker, Julian ; Boeken, Udo ; Maier, Sven ; Kersten, Alexander ; Meyns, Bart ; Pozzi, Matteo ; Pedersen, Finn M ; Schellongowski, Peter ; Kirali, Kaan ; Barrett, Nicholas ; Riera, Jordi ; Mueller, Thomas ; Belohlavek, Jan ; Lo Coco, Valeria ; Van der Horst, Iwan C C ; Van Bussel, Bas C T ; Schnabel, Ronny M ; Delnoij, Thijs ; Bolotin, Gil ; Lorini, Luca ; Schmiady, Martin O ; Schibilsky, David ; Kowalewski, Mariusz ; Pinto, Luis F ; Silva, Pedro E ; Kornilov, Igor ; Blandino Ortiz, Aaron ; Vercaemst, Leen ; Finney, Simon ; Roeleveld, Peter P ; Di Nardo, Matteo ; Hennig, Felix ; Antonini, Marta Velia ; Davidson, Mark ; Jones, Tim J ; Staudinger, Thomas ; Mair, Peter ; Kilo, Juliane ; Krapf, Christoph ; Erbert, Kathrin ; Peer, Andreas ; Bonaros, Nikolaos ; Kotheletner, Florian ; Krenner Mag, Niklas ; Shestakova, Liana ; Hermans, Greet ; Dauwe, Dieter ; Meersseman, Philippe ; Stockman, Bernard ; Nobile, Leda ; Lhereux, Olivier ; Nrasseurs, Alexandre ; Creuter, Jacques ; De Backer, Daniel ; Giglioli, Simone ; Michiels, Gregoire ; Foulon, Pierre ; Raes, Matthias ; Rodrigus, Inez ; Allegaert, Matthias ; Jorens, Philippe ; Debeucklare, Gerd ; Piagnerelli, Michael ; Biston, Patrick ; Peperstraete, Harlinde ; Vandewiele, Komeel ; Germay, Olivier ; Vandeweghe, Dimitri ; Havrin, Sven ; Bourgeois, Marc ; Lagny, Marc-Gilbert ; Alois, Genette ; Lavios, Nathalie ; Misset, Benoit ; Courcelle, Romain ; Timmermans, Philippe J ; Yilmaz, Alaaddin ; Vantomout, Michiel ; Lehaen, Jerone ; Jassen, Ame ; Guterman, Herbert ; Strauven, Maarten ; Lormans, Piet ; Verhamme, Bruno ; Vandewaeter, catherine ; Bonte, Frederik ; Vionne, Dominique ; Balik, Martin ; Blàha, Jan ; Lips, Michal ; Othal, Michal ; Bursa, Filip ; Spacek, Radim ; Christensen, Steffen ; Jorgensen, Vibeke ; Sorensen, Marc ; Madsen, Soren A ; Puss, Severin ; Beljantsev, Aleksandr ; Saiydoun, gabriel ; Fiore, Antonio ; Colson, Pascal ; Bazalgette, Florian ; Capdevila, Xavier ; Kollen, Sebastien ; Muller, Laurent ; Obadia, Jean-Francois ; Dubien, Pierre-Yves ; Ajrhourh, Lucrezia ; Guinot, Pierre G ; Zarka, Jonathan ; Besserve, Patricia ; Malfertheiner, Maximilian V ; Dreier, Esther ; Heinze, Birgit ; Akhyari, Payam ; Lichtenberg, Artur ; Aubin, Hug ; Assman, Alexander ; Saeed, Diyar ; Thiele, Holger ; Baumgaertel, Matthias ; Schmitto, Jan D ; Ruslan, Natanov ; Haverich, Axel ; Thielmann, Matthias ; Brenner, Thorsten ; Ruhpawar, Arjang ; Benk, Christoph ; Czerny, Martin ; Staudacher, Dawid L ; Beyersdorf, Fridhelm ; Kalbhenn, Johannes ; Henn, Philipp ; Popov, Aron-Frederik ; Iuliu, Torje ; Muellenbach, Ralf ; Reyher, Christian ; Rolfes, Caroline ; Lotz, Gosta ; Sonntagbauer, Michael ; Winkels, Helen ; Fichte, Julia ; Stohr, Robert ; Kalverkamp, Sebastian ; Karagiannidis, Christian ; Schafer, Simone ; Svetlitchny, Alexei ; Fichte, Julia ; Hopf, Hans-Bernd ; Jarczak, Dominik ; Groesdonk, Heinirich ; Rommer, Magdalena ; Hirsch, Jan ; Kaehny, Christian ; Soufleris, Dimitros ; Gavriilidis, Georgios ; Pontikis, Kostantinos ; Kyriakopoulou, Magdalini ; Kyriakoudi, Anna ; O'Brien, Serena ; Conrick-Martin, Ian ; Carton, Edmund ; Makhoul, Maged ; Ben-Ari, Josef ; Hadash, Amir ; Kogan, Alexander ; Kassif Lerner, Reut ; Abu-Shakra, Anas ; Matan, Moshe ; Balawona, Ahmad ; Kachel, Erez ; Altshuler, Roman ; Galante, Ori ; Fuchs, Lior ; Almog, Yaniv ; Ishay, Yaron S ; Lichter, Yael ; Gal-oz, Amir ; Carmi, Uri ; Nini, Asaph ; Soroksky, Arie ; Dekel, Hagi ; Rozman, Ziv ; Tayem, Emad ; Ilgiyaev, Eduard ; Hochman, Yuval ; Miltau, daniel ; Rapoport, Avigal ; Eden, Arieh ; Kompanietz, Dmitry ; Yousif, Michael ; Golos, Miri ; Grazioli, Lorenzo ; Ghitti, Davide ; Loforte, Antonio ; Di Luca, Daniela ; Baiocchi, Massimo ; Pacini, Davide ; Cappai, Antioco ; Meani, Paolo ; Mondino, Michele ; Russo, Claudio F ; Ranucci, Marco ; Fina, Dario ; Cotza, Marco ; Ballotta, Andrea ; Landoni, Giovanni ; Nardelli, Pasquale ; Fominski, Eygeny V ; Brazzi, Luca ; Montrucchio, Giorgia ; Sales, Gabriele ; Simonetti, Umberto ; Livigni, Sergio ; Silengo, Daniela ; Arena, Giulia ; Sovatzis, Stefania S ; Degani, Antonella ; Riccardi, Mariachiara ; Milanesi, Elisa ; Raffa, Giuseppe ; Martucci, Gennaro ; Arcadipane, Antonio ; Panarello, Giovanna ; Chiarini, Giovanni ; Cattaneo, Sergio ; Puglia, Carmine ; Benussi, Stefano ; Foti, Giuseppe ; Giani, Marco ; Bombino, Michela ; Costa, Maria Cristina ; Rona, Roberto ; Avalli, Leonello ; Donati, Abele ; Carozza, Roberto ; Gasparri, Francesco ; Carsetti, Andrea ; Picichè, Marco ; Marinello, Anna ; Danzi, Vinicio ; Zanin, Anita ; Condello, Ignazio ; Fiore, Flavio ; Moscarelli, Marco ; Nasso, Giuseppe ; Speziale, Giuseppe ; Sandrelli, Luca ; Montalto, Andrea ; Musumeci, Francesco ; Circelli, Alessandro ; Russo, Emanuele ; Agnoletti, Vanni ; Rociola, Ruggero ; Milano, Aldo D ; Pilato, Emanuele ; Comentale, Giuseppe ; Montisci, Andrea ; Alessandri, Francesco ; Tosi, Antonella ; Pugliese, Francesco ; Giordano, Giovanni ; Carelli, Simone ; Grieco, Domenico L ; Dell'Anna, Antonio M ; Antonelli, Massimo ; Ramoni, Enrico ; Zulueta, Josè ; Del Giglio, Mauro ; Petracca, Sebastiano ; Bertini, Pietro ; Guarracino, Fabio ; De Simone, Luigi ; Angeletti, Paolo M ; Forfori, Francesco ; Taraschi, Francesco ; Quintiliani, Veronica N ; Samalavicius, Robertas ; Jankuviene, Agne ; Scupakova, Nadezda ; Urbonas, Karolis ; Kapturauskas, Juozas ; Soerensen, Gro ; Suwalski, Piotr ; Linhares Santos, Luis ; Marques, Ana ; Miranda, Marisa ; Teixeira, Sonia ; Salgueiro, Andrea ; Pereira, Filipe ; Ketskalo, Michail ; Tsarenko, Sergey ; Shilova, Alexandra ; Afukov, Ivan ; Popugaev, Konstantin ; Minin, Sergei ; Shelukhin, Daniil ; Malceva, Olga ; Gleb, Moroz ; Skopets, Alexander ; Kornelyuk, Roman ; Kulikov, Alexandr ; Okhrimchuk, Vadim ; Turchaninov, Alexandr ; Shelukhin, Daniil ; Petrushin, Maxim ; Sheck, Anastasia ; Mekulov, Akhmed ; Ciryateva, Svetlana ; Urusov, Dmitry ; Gorjup, Vojka ; Golicnik, Alenka ; Goslar, Tomaz ; Ferrer, Ricard ; Martinez-Martinez, Maria ; Argudo, Eduard ; Palmer, Neiser ; De Pablo Sanchez, Raul ; Juan Higuera, Lucas ; Arnau Blasco, Lucas ; Marquez, Josè A ; Sbraga, Fabrizio ; Fuset, Mari Paz ; De Gopegui, Pablo Ruiz ; Claraco, Luis M ; De Ayala, Josè A ; Peiro, Maranta ; Ricart, Pilar ; Martinez, Sergio ; Chavez, Fernando ; Fabra, Marc ; Sandoval, elena ; Toapanta, David ; Carraminana, Albert ; Tellez, Adrian ; Ososio, Jeysson ; Milan, Pablo ; Rodriguez, Jorge ; Andoni, Garcia ; Gutierrez, Carola ; Perez de la Sota, Enrique ; Eixeres-Esteve, Andrea ; Garcia-Maellas, Maria Teresa ; Gutierrez-Gutierrez, Judit ; Arboleda-Salazar, Rafael ; Santa Teresa, Patricia ; Jaspe, Alexis ; Garrido, Alberto ; Castaneda, Galo ; Alcantara, Sara ; Martinez, Nuria ; Perez, Marina ; Villanueva, Hector ; Vidal Gonzalez, Anxela ; Paez, Juan ; Santon, Arnoldo ; Perez, Cesar ; Lopez, Marta ; Rubio Lopez, Maria Isabel ; Gordillo, Antonio ; Naranjo-Izurieta, Jose ; Munoz, Javier ; Alcalde, Immaculada ; Onieva, Fernando ; Gimeno Costa, Ricardo ; Perez, Francisco ; Madrid, Isabel ; Gordon, Monica ; Albacete Moreno, Carlos L ; Perez, Daniel ; Lopez, Nayara ; Martinenz, Domingo ; Blanco-Schweizer, Pablo ; Diez, Cristina ; Perez, David ; Prieto, Ana ; Renedo, Gloria ; Bustamante, Elena ; Cicuendez, Ramon ; Citores, Rafael ; Boado, Victoria ; Garcia, Katherine ; Voces, Roberto ; Domezain, Monica ; Nunez Martinez, Jose Maria ; Vicente, Raimundo ; Martin, David ; Andreu, Antonio ; Gomez Casal, Vanesa ; Chico, Ignacio ; Menor, Eva Maria ; Vara, Sabela ; Gamacho, Jose ; Perez-Chomon, Helen ; Javier Gonzales, Francisco ; Barrero, Irene ; Martin-Villen, Luis ; Fernandez, Esperanza ; Mendoza, Maria ; Navarro, Joaquin ; Colomina Climent, Joaquin ; Gonzales-Perez, Alfredo ; Muniz-Albaceita, Guillermo ; Amado, Laura ; Rodriguez, Raquel ; Ruiz, Emilio ; Eiras, Maria ; Grins, Edgars ; Magnus, Rosen ; Kanetoft, Mikael ; Eidevald, Marcus ; Watson, Pia ; Vogt, Paul R ; Steiger, Peter ; Aigner, Tobias ; Weber, Alberto ; Grunefelder, Jurg ; Kunz, Martin ; Grapow, Martin ; Aymard, Thierry ; Reser, Diana ; Agus, Gianluca ; Consiglio, Jolanda ; Haenggi, Matthias ; Hansjoerg, Jenni ; Iten, Manuela ; Doeble, Thomas ; Zenklusen, Urs ; Bechtold, Xavier ; Faedda, Giovanni ; Iafrate, Manuel ; Rohjer, Amanda ; Bergamaschi, Layla ; Maessen, Jos ; Reis Miranda, Dinis ; Endeman, H ; Gommers, D ; Meuwese, C ; Maas, Jacinta ; Van Gijlswijk, MJ ; Van Berg, RN ; Candura, Dario ; Van der Linden, Marcel ; Kant, Merijin ; Van der Heijden, JJ ; Scholten, Eric ; Van Belle-van Haren, Nicole ; Lagrand, WK ; Vlaar, Alexander P ; De Jong, Syste ; Cander, Basar ; Sargin, Murat ; Ugur, Murat ; Kaygin, Mehmet A ; Daly, Kathleen ; Agnew, Nicola ; Head, Laura ; Kelly, Laura ; Anoma, Gunawardena ; Russell, Clare ; Aquino, Verna ; Scott, Ian ; Flemming, Lucy ; Gillon, Stuart ; Moore, Olivia ; Gelandt, Elton ; Auzinger, George ; Patel, Sameer ; Loveridge, Robert | Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | The Lancet Respiratory Medicine | ||||
| Verlag: | ELSEVIER SCI LTD | ||||
| Ort der Veröffentlichung: | OXFORD | ||||
| Band: | 11 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 2 | ||||
| Seitenbereich: | S. 151-162 | ||||
| Datum: | 2023 | ||||
| Institutionen: | Medizin > Lehrstuhl für Innere Medizin II | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | QUALITY-OF-LIFE; COHORT; | ||||
| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Ja | ||||
| Dokumenten-ID: | 76284 |
Zusammenfassung
Background Extracorporeal membrane oxygenation (ECMO) has been widely used in patients with COVID-19, but uncertainty remains about the determinants of in-hospital mortality and data on post-discharge outcomes are scarce. The aims of this study were to investigate the variables associated with in-hospital outcomes in patients who received ECMO during the first wave of COVID-19 and to describe the ...

Zusammenfassung
Background Extracorporeal membrane oxygenation (ECMO) has been widely used in patients with COVID-19, but uncertainty remains about the determinants of in-hospital mortality and data on post-discharge outcomes are scarce. The aims of this study were to investigate the variables associated with in-hospital outcomes in patients who received ECMO during the first wave of COVID-19 and to describe the status of patients 6 months after ECMO initiation.Methods EuroECMO-COVID is a prospective, multicentre, observational study developed by the European Extracorporeal Life Support Organization. This study was based on data from patients aged 16 years or older who received ECMO support for refractory COVID-19 during the first wave of the pandemic-from March 1 to Sept 13, 2020-at 133 centres in 21 countries. In-hospital mortality and mortality 6 months after ECMO initiation were the primary outcomes. Mixed-Cox proportional hazards models were used to investigate associations between patient and management-related variables (eg, patient demographics, comorbidities, pre-ECMO status, and ECMO characteristics and complications) and in-hospital deaths. Survival status at 6 months was established through patient contact or institutional charts review. This study is registered with ClinicalTrials.gov, NCT04366921, and is ongoing.Findings Between March 1 and Sept 13, 2020, 1215 patients (942 [78%] men and 267 [22%] women; median age 53 years [IQR 46-60]) were included in the study. Median ECMO duration was 15 days (IQR 8-27). 602 (50%) of 1215 patients died in hospital, and 852 (74%) patients had at least one complication. Multiorgan failure was the leading cause of death (192 [36%] of 528 patients who died with available data). In mixed-Cox analyses, age of 60 years or older, use of inotropes and vasopressors before ECMO initiation, chronic renal failure, and time from intubation to ECMO initiation of 4 days or more were associated with higher in-hospital mortality. 613 patients did not die in hospital, and 547 (95%) of 577 patients for whom data were available were alive at 6 months. 102 (24%) of 431 patients had returned to full-time work at 6 months, and 57 (13%) of 428 patients had returned to part-time work. At 6 months, respiratory rehabilitation was required in 88 (17%) of 522 patients with available data, and the most common residual symptoms included dyspnoea (185 [35%] of 523 patients) and cardiac (52 [10%] of 514 patients) or neurocognitive (66 [13%] of 512 patients) symptoms.Interpretation Patient's age, timing of cannulation (<4 days vs >= 4 days from intubation), and use of inotropes and vasopressors are essential factors to consider when analysing the outcomes of patients receiving ECMO for COVID-19. Despite post-discharge survival being favourable, persisting long-term symptoms suggest that dedicated post-ECMO follow-up programmes are required.Funding None.Copyright (c) 2022 Published by Elsevier Ltd. All rights reserved.
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