Germline predisposition traits in allogeneic hematopoietic stem-cell transplantation for myelodysplastic syndromes: a survey-based study and position paper on behalf of the Chronic Malignancies Working Party of the EBMT

Gurnari, Carmelo ; Robin, Marie ; Godley, Lucy A ; Drozd-Sokołowska, Joanna ; Włodarski, Marcin W ; Raj, Kavita ; Onida, Francesco ; Worel, Nina ; Ciceri, Fabio ; Carbacioglu, Selim ; Kenyon, Michelle ; Aljurf, Mahmoud ; Bonfim, Carmem ; Makishima, Hideki ; Niemeyer, Charlotte ; Fenaux, Pierre ; Zebisch, Armin ; Hamad, Nada ; Chalandon, Yves ; Hellström-Lindberg, Eva ; Voso, Maria Teresa ; Mecucci, Cristina ; Duarte, Fernando Barroso ; Sebert, Marie ; Sicre de Fontbrune, Flore ; Soulier, Jean ; Shimamura, Akiko ; Lindsley, R Coleman ; Maciejewski, Jarosław P ; Calado, Rodrigo T ; Yakoub-Agha, Ibrahim ; McLornan, Donal P

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Alternative Links zum Volltext:DOIVerlag

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Details

Dokumentenart:	Artikel
Titel eines Journals oder einer Zeitschrift:	The Lancet Haematology
Verlag:	ELSEVIER SCI LTD
Ort der Veröffentlichung:	London
Band:	10
Nummer des Zeitschriftenheftes oder des Kapitels:	12
Seitenbereich:	e994-e1005
Datum:	2023
Institutionen:	Medizin > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation
Identifikationsnummer:	Wert Typ 10.1016/S2352-3026(23)00265-X DOI
Stichwörter / Keywords:	BONE-MARROW FAILURE; ACUTE MYELOID-LEUKEMIA; FANCONI-ANEMIA; CONDITIONING REGIMEN; CHILDREN; VARIANTS; BLOOD; CLASSIFICATION; COMPLICATIONS; GUIDELINES
Dewey-Dezimal-Klassifikation:	600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin
Status:	Veröffentlicht
Begutachtet:	Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:	Ja
Dokumenten-ID:	76312

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Zusammenfassung

The recent application of whole exome or whole genome sequencing unveiled a plethora of germline variants predisposing to myeloid disorders, particularly myelodysplastic neoplasms. The presence of such variants in patients with myelodysplastic syndromes has important clinical repercussions for haematopoietic stem-cell transplantation, from donor selection and conditioning regimen to ...

Zusammenfassung

The recent application of whole exome or whole genome sequencing unveiled a plethora of germline variants predisposing to myeloid disorders, particularly myelodysplastic neoplasms. The presence of such variants in patients with myelodysplastic syndromes has important clinical repercussions for haematopoietic stem-cell transplantation, from donor selection and conditioning regimen to graft-versus-host disease prophylaxis and genetic counselling for relatives. No international guidelines exist to harmonise management approaches to this particular clinical scenario. Moreover, the application of germline testing, and how this informs clinical decisions, differs according to the expertise of individual clinical practices and according to different countries, health-care systems, and legislations. Leveraging the global span of the European Society for Blood and Marrow Transplantation (EBMT) network, we took a snapshot of the current European situation on these matters by disseminating an electronic survey to EBMT centres experienced in myelodysplastic syndromes transplantation. An international group of haematologists, transplantation physicians, paediatricians, nurses, and experts in molecular biology and constitutional genetics with experience in myelodysplastic syndromes contributed to this Position Paper. The panel met during multiple online meetings to discuss the results of the EBMT survey and to establish suggested harmonised guidelines for such clinical situations, which are presented here.

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