- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-764191
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.76419
Zusammenfassung
Phototoxicity and skin cancer are severe adverse effects of the anti-fungal drug voriconazole (VOR). These adverse effects resemble those seen in xeroderma pigmentosum, caused by defective DNA nucleotide excision repair (NER), and we show that VOR decreases NER capacity. We show that VOR treatment does not perturb the expression of NER, or other DNA damage-related genes, but that VOR localizes to ...

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