Polyol pathway-generated fructose is indispensable for growth and survival of non-small cell lung cancer

URN to cite this document:: urn:nbn:de:bvb:355-epub-765616
DOI to cite this document:: 10.5283/epub.76561

Schwab, Annemarie ; Siddiqui, Mohammad Aarif ; Ramesh, Vignesh ; Gollavilli, Paradesi Naidu ; Turtos, Adriana Martinez ; Møller, Sarah Søgaard ; Pinna, Luisa ; Havelund, Jesper F ; Rømer, Anne Mette A ; Ersan, Pelin Gülizar ; Parma, Beatrice ; Marschall, Sabine ; Dettmer, Katja

; Alhusayan, Mohammed ; Bertoglio, Pietro ; Querzoli, Giulia ; Mielenz, Dirk ; Sahin, Ozgur ; Færgeman, Nils J ; Asangani, Irfan A ; Ceppi, Paolo

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Date of publication of this fulltext: 14 Apr 2025 06:40

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Abstract

Despite recent treatment advances, non-small cell lung cancer (NSCLC) remains one of the leading causes of cancer-related deaths worldwide, and therefore it necessitates the exploration of new therapy options. One commonly shared feature of malignant cells is their ability to hijack metabolic pathways to confer survival or proliferation. In this study, we highlight the importance of the polyol ...