Cell type-specific modulation of metabolic, immune-regulatory, and anti-microbial pathways by CD101

URN to cite this document:: urn:nbn:de:bvb:355-epub-765655
DOI to cite this document:: 10.5283/epub.76565

Wrage, Marius ; Holland, Tim ; Nüse, Björn ; Kaltwasser, Johanna ; Fröhlich, Jessica ; Arnold, Harald ; Gießler, Claudia ; Flamann, Cindy ; Bruns, Heiko ; Berges, Johannes ; Daniel, Christoph ; Hoffmann, Markus H. ; Anish, Chakkumkal ; Seeberger, Peter H. ; Bogdan, Christian ; Dettmer, Katja

; Rauh, Manfred ; Mattner, Jochen

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Date of publication of this fulltext: 14 Apr 2025 05:42

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Abstract

T lymphocytes and myeloid cells express the immunoglobulin-like glycoprotein cluster of differentiation (CD)101, notably in the gut. Here, we investigated the cell-specific functions of CD101 during dextran sulfate sodium (DSS)-induced colitis and Salmonella enterica Typhimurium infection. Similar to conventional CD101 mice, animals with a regulatory T cell-specific Cd101 deletion developed more ...