Metabolomic profiling of renal cyst fluid in advanced ADPKD: insights from dialysis and transplantation cohorts

URN to cite this document:: urn:nbn:de:bvb:355-epub-770006
DOI to cite this document:: 10.5283/epub.77000

Heckscher, Simon ; Ihlo, Nicolas A. ; Schueler, Jan ; Kellermeier, Fabian ; Werner, Jens M.

; Nuebel, Barbara ; Gross, Verena ; May, Matthias ; Wullich, Bernd ; Kammerl, Martin ; Gnewuch, Carsten ; Burkhardt, Ralph

; Buchholz, Björn ; Pion, Eric ; Aung, Thiha ; Banas, Miriam ; Schlitt, Hans J.

; Oefner, Peter J.

; Dettmer, Katja

; Gronwald, Wolfram

; Behr, Merle

; Haerteis, Silke

; Schmidt, Katharina M.

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 02 Jul 2025 09:49

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Abstract

Background Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disorder characterized by progressive renal cyst formation, often leading to end-stage kidney disease (ESKD). In contrast to the urinary metabolome in ADPKD, the composition of renal cyst fluid remains largely unexplored. Methods We conducted a comprehensive metabolomic analysis of renal cyst ...