Chimeric Antigen Receptor (CAR) T Cells Releasing Soluble SLAMF6 Isoform 2 Gain Superior Anti-Cancer Cell Functionality in an Auto-Stimulatory Fashion

URN to cite this document:: urn:nbn:de:bvb:355-epub-770385
DOI to cite this document:: 10.5283/epub.77038

Harrer, Dennis Christoph

; Schlierkamp-Voosen, Tim ; Barden, Markus ; Pan, Hong ; Xydia, Maria ; Herr, Wolfgang ; Dörrie, Jan ; Schaft, Niels ; Abken, Hinrich

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 02 Jul 2025 16:24

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Abstract

T cells equipped with chimeric antigen receptors (CARs) have evolved into an essential pillar of lymphoma therapy, reaching second-line treatment. In solid cancers, however, a dearth of lasting CAR T cell activation poses the major obstacle to achieving a substantial and durable anti-tumor response. To extend T cell cytotoxic capacities, we engineered CAR T cells to constitutively release an ...