Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma

DOI zum Zitieren dieses Dokuments:: 10.5283/epub.775

Hellerbrand, Claus ; Mühlbauer, Marcus ; Wallner, Susanne ; Schuierer, Marion ; Behrmann, Iris ; Bataille, Frauke ; Weiss, Thomas S.

; Schölmerich, Jürgen ; Bosserhoff, Anja-Katrin

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Veröffentlichungsdatum dieses Volltextes: 05 Aug 2009 13:24

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Zusammenfassung

The methylthioadenosine phosphorylase (MTAP) gene is localized in the chromosomal region 9p21. Here, frequently homozygous deletions occur in several kinds of cancer associated with the loss of tumour suppressor genes as p16 and p15. The aim of this study was to analyse MTAP expression in hepatocellular carcinoma (HCC) and to get an insight into the regulation and functional role of MTAP in ...