Novel water-soluble and highly efficient dual type I/II next generation inhibitors of FMS-like tyrosine kinase 3 (FLT3)

URN to cite this document:: urn:nbn:de:bvb:355-epub-775424
DOI to cite this document:: 10.5283/epub.77542

Sellmer, Andreas ; Able, Marina ; Spiekermann, Karsten ; Reinecke, Maria ; Kuster, Bernhard ; Utpatel, Kirsten

; Wirth, Lukas ; Pongratz, Herwig ; Plank, Nicole ; Koch, Pierre

; Elz, Sigurd ; Fischer, Amrei ; Tizazu, Belay ; Fiebig, Heinz-Herbert ; Dove, Stefan ; Mahboobi, Siavosh

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 14 Aug 2025 09:46

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Abstract

Mutations of the FMS-like tyrosine kinase (FLT3) occur in acute myeloid leukemia (AML) and are associated with very poor prognosis. Available FLT3 inhibitors are potent but either show a lack of selectivity regarding other tyrosine kinases or only transient efficacy due to emerging resistance under therapy. Water-soluble derivatives of the tyrosine kinase inhibitor Marbotinib are highly selective ...