Direct ink writing of sustainable multifunctional biodegradable porous Fe-eggshell scaffolds

URN to cite this document:: urn:nbn:de:bvb:355-epub-775714
DOI to cite this document:: 10.5283/epub.77571

Putra, Niko E. ; Youf, Raphaëlle

; Moosabeiki, Vahid ; Leeflang, Marius A. ; Klimopoulou, Maria ; Mirzaali, Mohammad J. ; Mol, Arjan ; Riool, Martijn

; Fratila-Apachitei, Lidy E. ; Zhou, Jie ; Apachitei, Iulian ; Zadpoor, Amir A.

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 25 Aug 2025 12:04

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Abstract

Medical devices contribute to the carbon footprint generated by the healthcare sector. The development of implants and biomaterials using recycled waste materials promotes sustainable advances in tissue engineering. Additively manufactured (AM) bone-substituting biomaterials with multifunctional properties, e.g., biodegradability, antibacterial and osteogenic potential, can contribute to sustainable healthcare. Biodegradable biomaterials eliminate secondary surgeries to remove implants, reduce post-surgical complications, and enhance patient recovery, thus decreasing the energy usage and waste associated with medical treatments. Herein, we present porous iron (Fe) scaffolds incorporating 20 vol% waste-derived eggshell particles for bone substitution. The Fe-eggshell scaffolds were fabricated using direct ink writing (DIW) technique and underwent post-AM heat treatment. During sintering, the eggshell’s main component – CaCO3, transformed into CaO. Atomic diffusion between α-Fe and CaO phases resulted in the formation of Ca2Fe2O5 phase at the interface. The scaffolds were 70 % porous and displayed a biodegradation rate of 0.11 mm/year. The mechanical properties were comparable to trabecular bone and the scaffolds endured 3 million loading cycles at 0.7σy in r-SBF. The scaffolds showed apatite-forming ability, evidenced by the formation of (carbonaceous) hydroxyapatite, which are conducive to preosteoblast adhesion, proliferation, and differentiation. RT-qPCR analysis confirmed the osteogenic potential of the specimens as evidenced by the upregulated expression of osteopontin and osteocalcin as compared to Ti6Al4V controls. Furthermore, the scaffolds exhibited bactericidal activity (>3.9-log CFU reduction) against methicillin-sensitive and multidrug-resistant strains of Staphylococcus aureus and delayed their biofilm formation. Our research showcases the exceptional multifunctionality of DIW Fe-eggshell composite scaffolds for the sustainable development of orthopedic biomaterials.

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