4D structural biology: quantitative dynamics in the eukaryotic RNA exosome complex

URN to cite this document:: urn:nbn:de:bvb:355-epub-775829
DOI to cite this document:: 10.5283/epub.77582

Liebau, Jobst ; Lazaretti, Daniela ; Fürtges, Torben ; Bichler, Anna ; Pilsl, Michael ; Rudack, Till

; Sprangers, Remco

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 02 Sep 2025 09:50

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Abstract

Molecular machines play pivotal roles in all biological processes. Most structural methods, however, are unable to directly probe molecular motions. Here, we demonstrate that dedicated NMR experiments can provide quantitative insights into functionally important dynamic regions in very large asymmetric protein complexes. We establish this for the 410 kDa eukaryotic RNA exosome complex that ...