Hypoxia‐inducible factor‐2 stabilization is not sufficient to induce erythropoietin production in deeper medullary fibroblasts

URN to cite this document:: urn:nbn:de:bvb:355-epub-775941
DOI to cite this document:: 10.5283/epub.77594

Firmke, Bettina K. M. ; Fuchs, Michaela A. A. ; Süß, Lena M. ; Forst, Anna‐Lena ; Kurtz, Armin ; Broeker, Katharina A.‐E.

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Date of publication of this fulltext: 27 Aug 2025 08:05

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Abstract

Under hypoxaemic conditions, cortical fibroblasts primarily produce erythropoietin (EPO). However, we have previously shown that most interstitial fibroblasts positive for platelet-derived growth factor receptor β (PDGFR-β) in all kidney zones are also able to produce EPO. Therefore, we wondered if either the physiological stimuli might not be sufficient to stabilize the hypoxia-inducible factor ...