Adenovirus maturation establishes the transcription competent packaging of its genome

URN to cite this document:: urn:nbn:de:bvb:355-epub-780825
DOI to cite this document:: 10.5283/epub.78082

Baumgartl, Conradin ; Holzinger, Simon

; Schwartz, Uwe

; Franken, Linda E ; Grünewald, Kay ; Wodrich, Harald ; Längst, Gernot

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 18 Nov 2025 08:50

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Abstract

Adenoviruses are human pathogens that more recently have gathered interest as tools for human gene therapy and vaccination. The maturation of the viral genome with associated proteins (core) remains largely unexplored. Here, we show that adenovirus core maturation is guided by features embedded in the viral DNA sequence, which primes the genome for transcription. Using DMS-seq to compare the ...