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Striatal deafferentation increases dopaminergic neurogenesis in the adult olfactory bulb

Winner, Beate, Geyer, Martin, Couillard-Despres, Sebastien, Aigner, Robert, Bogdahn, Ulrich, Aigner, Ludwig, Kuhn, Georg and Winkler, Jürgen (2006) Striatal deafferentation increases dopaminergic neurogenesis in the adult olfactory bulb. Experimental neurology 197 (1), pp. 113-121.

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Date of publication of this fulltext: 05 Aug 2009 13:24

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Other URL: http://dx.doi.org/10.1016/j.expneurol.2005.08.028


Abstract

Dopaminergic loss is known to be one of the major hallmarks of Parkinson disease (PD). In addition to its function as a neurotransmitter, dopamine plays significant roles in developmental and adult neurogenesis. Both dopaminergic deafferentation and stimulation modulate proliferation in the subventricular zone (SVZ)/olfactory bulb system as well as in the hippocampus. Here, we study the impact of ...

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Item type:Article
Date:January 2006
Institutions:Medicine > Lehrstuhl für Neurologie
Identification Number:
ValueType
16246330PubMed ID
10.1016/j.expneurol.2005.08.028DOI
Keywords:Parkinson disease; Lesion; Adult neurogenesis; Neural progenitor/stem cell; BrdU; TH; Pax-6; Cell fate; 6-OHDA
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:789
Owner only: item control page

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