Striatal deafferentation increases dopaminergic neurogenesis in the adult olfactory bulb

DOI to cite this document:: 10.5283/epub.789

Winner, Beate ; Geyer, Martin ; Couillard-Despres, Sebastien ; Aigner, Robert ; Bogdahn, Ulrich ; Aigner, Ludwig ; Kuhn, Georg ; Winkler, Jürgen

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Date of publication of this fulltext: 05 Aug 2009 13:24

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Abstract

Dopaminergic loss is known to be one of the major hallmarks of Parkinson disease (PD). In addition to its function as a neurotransmitter, dopamine plays significant roles in developmental and adult neurogenesis. Both dopaminergic deafferentation and stimulation modulate proliferation in the subventricular zone (SVZ)/olfactory bulb system as well as in the hippocampus. Here, we study the impact of ...