The influence of endogenous surfactant on the structure and drug-release properties of Eudragit NE30D-matrixes

URN to cite this document:: urn:nbn:de:bvb:355-epub-90157
DOI to cite this document:: 10.5283/epub.9015

Göpferich, Achim ; Lee, Geoffrey

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Date of publication of this fulltext: 14 Aug 2009 11:46

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Abstract

The influence of an endogenous surfactant present in Eudragit NE30D on the structure and drug release (clenbuterol) properties of thin matrices has been examined. Both drug-free and drug-loaded matrices were found to be non-isotropic in structure, the former having a marbled appearance under the polarising light microscope, and the latter showing numerous needle-shaped crystals. At loading above ...