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Funktionelle Untersuchungen zur Expression des Interleukin-11 Rezeptors alpha in humanen Kolonepithelzellen

Kießling, Stephan (2002) Funktionelle Untersuchungen zur Expression des Interleukin-11 Rezeptors alpha in humanen Kolonepithelzellen. PhD, Universität Regensburg.

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Date of publication of this fulltext: 09 Apr 2002 13:40

Abstract (German)

Die Kolonkarzinomzelllinie HT-29 und isolierte primäre humane Kolonepithelzellen (CEC) exprimierten auf Transkriptions- und Translationsebene die a-Kette des Rezeptors für den spezifischen Liganden IL-11 und das Glykoprotein gp130. Ferner konnten wir nachweisen, dass eine Stimulation der Kolonepithelzellen eine dosis- und zeitabhängige Phosphorylierung des Jak/STAT-Signalweges in diesen Zellen ...


Translation of the abstract (English)

A potential protective or anti-inflammatory effect of interleukin-11 (IL-11) for the intestinal mucosa has been postulated from several animal models of inflammatory bowel disease (IBD) and mucosal damage. Therefore, IL-11 was considered to be a promising drug candidate for the treatment of IBD. We could recently demonstrate functional IL-11Ralpha expression being restricted to epithelial cells ...


Export bibliographical data

Item type:Thesis of the University of Regensburg (PhD)
Date:8 April 2002
Referee:PD Dr. Gerhard Rogler and Prof. Dr. Armin Buschauer
Date of exam:28 March 2002
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:Epithelzelle, Apoptosis, Rezeptor, Cytokin , Interleukin-11 , Interleukin-11, colon
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:9909
Owner only: item control page


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