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Influence of E-LDL and Ox-LDL on the metabolism of ApoE, cholesterol, sphingolipids and glycosphingolipids as well as on the raft-composition in human macrophages

URN to cite this document: urn:nbn:de:bvb:355-opus-6163

Grandl, Margot (2006) Influence of E-LDL and Ox-LDL on the metabolism of ApoE, cholesterol, sphingolipids and glycosphingolipids as well as on the raft-composition in human macrophages. PhD, Universität Regensburg

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Abstract (English)

A hallmark in atherosclerosis is the generation of lipid loaded macrophage foam cells. In this thesis the effects of the different atherogenic lipoproteins, enzymatically modified LDL (E-LDL) and mildly oxidized LDL (Ox-LDL) on cellular cholesterol, sphingolipid and glycosphingolipid (GSL) metabolism, raft microdomain generation and cell surface receptor expression during in vitro foam cell ...

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Translation of the abstract (German)

Hauptmerkmal der Arteriosklerose ist die Bildung von Lipid beladenen Makrophagen so genannten Schaumzellen. In dieser Arbeit wurden die Einflüsse der unterschiedlichen atherogenen Lipoproteine, enzymatisch modifiziertes LDL (E-LDL) und mild oxidiertes LDL (Ox-LDL) auf den zellulären Cholesterol, Sphingolipid und Glycosphingolipid (GSL) Metabolismus, die Raft-Microdomänen Bildung sowie der ...

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Item Type:Thesis of the University of Regensburg (PhD)
Date:6 July 2006
Referee:Prof. Dr. Armin Buschauer and Prof. Dr. G. Schmitz
Date of exam:20 February 2006
Institutions:Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:Monozyten-Makrophagen-System , Schaumzelle , Arteriosklerose , Low-density-Lipoproteine , Sphingolipide , Glykosphingolipide , Sphingolipidstoffwechsel , Cholesterinstoffwechsel , Apoenzym , E-LDL , Ox-LDL , Rafts , Apo-E , E-LDL , Ox-LDL , Rafts , Apo-E
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:27 Oct 2009 07:45
Last Modified:13 Mar 2014 11:38
Item ID:10433
Owner Only: item control page

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