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Protein-protein interactions mediated by Cys2His2 zinc-fingers

URN to cite this document: urn:nbn:de:bvb:355-opus-6806

Giesecke, Astrid (2006) Protein-protein interactions mediated by Cys2His2 zinc-fingers. PhD, Universität Regensburg

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Abstract (English)

The C2H2 zinc finger motif is a compact ~ 30 amino acid molecular recognition domain that comprises a beta-hairpin followed by an alpha-helix. These domains are typically found as tandem arrays that mediate specific interactions with various macromolecules including DNA, RNA and other proteins. Although very well characterized as a DNA-binding domain, relatively little is currently understood ...

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Translation of the abstract (German)

Das C2H2 Zink Finger Motiv besteht aus etwa 30 Aminosäuren, die eine kompakte Zink-bindende Domäne bilden. In Proteinen kommt dieses Motiv gewöhnlich als repetitive Einheit vor, die aus einer antiparallelen beta-Haarnadel und einer alpha-Helix besteht. C2H2 Zinkfinger Domänen können mit verschiedenen Makromolekülen wie z.B. DNA, RNA und Proteinen spezifische Interaktionen eingehen und sind in ...

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Export bibliographical data

Item Type:Thesis of the University of Regensburg (PhD)
Date:5 November 2006
Referee:Reinhard (Prof. Dr.) Sterner
Date of exam:27 June 2006
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Reinhard Sterner
Keywords:Zink-Finger-Proteine , Proteindesign , Protein-Protein-Wechselwirkung , Bakterielles Two-Hybrid System , Ikaros/Hunchback Transkriptionsfaktor , Bacterial Two-Hybrid System , Ikaros/Hunchback Transcriptionfactor
Subjects:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:27 Oct 2009 07:49
Last Modified:13 Mar 2014 11:40
Item ID:10463
Owner Only: item control page
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