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Id3, inhibitor of DNA binding and cell differentiation: synthesis and conformational analysis of the full-length protein and its truncated analogues

URN to cite this document: urn:nbn:de:bvb:355-opus-8133

Svobodová, Jaroslava (2007) Id3, inhibitor of DNA binding and cell differentiation: synthesis and conformational analysis of the full-length protein and its truncated analogues. PhD, Universität Regensburg

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Abstract (English)

The Dissertation deals with the synthesis and characterization of Id3 which is the smallest member of the Id protein family. It is a negative regulator of the bHLH transcription factors; by the formation of heterodimers with the bHLH proteins, Id3 prevents their binding to DNA and hence the transcriptional activation. This eventually leads to increased cell proliferation and reduced cell ...

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Translation of the abstract (German)

Die Dissertation behandelt die Synthese und Charakterisierung von Id3, welches das kleinste Mitglied der Id-Protein Familie ist. bHLH-Transkriptionsfaktoren werden negativ reguliert: durch Bildung von Heterodimeren mit diesen bHLH-Proteinen verhindert Id3 ihre Bindung an die DNA und demzufolge die Aktivierung der Transkription. Letztendlich führt dies zu zunehmender Zell-Proliferation und ...

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Export bibliographical data



Item Type:Thesis of the University of Regensburg (PhD)
Date:25 June 2007
Referee:Dr. Chiara Cabrele
Date of exam:20 April 2007
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Dr. Chiara Cabrele
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:CD-Spektroskopie , Fluoreszenz-Resonanz-Energie-Transfer , Konformation , DNS-Bindung , Inhibitorproteine , Zelldifferenzierung , Chemische Synthese , , Id3 Protein , SPPS , HLH motif
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:27 Oct 2009 12:00
Last Modified:13 Mar 2014 11:47
Item ID:10566
Owner Only: item control page

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