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Protein design on computers. Five new proteins: Shpilka, Grendel, Fingerclasp, Leather, and Aida

Sander, Chris and Vriend, Gerrit and Bazan, Fernando and Horovitz, Amnon and Nakamura, Haruki and Ribas, Luis and Finkelstein, Alexei V. and Lockhart, Andrew and Merkl, Rainer and Perry, L. Jeanne and Emery, Stephen C. and Gaboriaud, Christine and Marks, Cara and Moult, John and Verlinde, Christophe and Eberhard, Marc and Elofsson, Arne and Hubbard, Tim J. P. and Regan, Lynne and Banks, Jay and Jappelli, Roberto and Lesk, Arthur M. and Tramontano, Anna (1992) Protein design on computers. Five new proteins: Shpilka, Grendel, Fingerclasp, Leather, and Aida. Proteins 12 (2), pp. 105-110.

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Other URL: http://www3.interscience.wiley.com/journal/107610999/abstract


What is the current state of the art in protein design? This question was approached in a recent two-week protein design workshop sponsored by EMBO and held at the EMBL in Heidelberg. The goals were to test available design tools and to explore new design strategies. Five novel proteins were designed: Shpilka, a sandwich of two four-stranded beta-sheets, a scaffold on which to explore variations ...


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Item type:Article
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Rainer Merkl
Identification Number:
1603799PubMed ID
Amino Acid SequenceMESH
Carrier Proteins/chemistry*MESH
Carrier Proteins/metabolismMESH
Molecular Sequence DataMESH
Protein ConformationMESH
Protein Engineering*MESH
Recombinant Proteins*MESH
Keywords:Algorithms Amino Acid Sequence Carrier Proteins/*chemistry/metabolism Computers Flavodoxin/metabolism Molecular Sequence Data NAD/metabolism Protein Conformation *Protein Engineering Proteins/*chemistry/metabolism Support, Non-U.S. Gov't
Dewey Decimal Classification:500 Science > 570 Life sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Deposited on:16 Nov 2009 09:59
Last modified:21 Dec 2009 07:46
Item ID:10933
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