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Effect of N,N'-diethyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines on the DMBA-induced mammary carcinoma of the rat

Angerer, Erwin von (1982) Effect of N,N'-diethyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines on the DMBA-induced mammary carcinoma of the rat. Journal of Medicinal Chemistry 25 (11), pp. 1374-1377.

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Abstract

The syntheses and estrogen receptor affinities of meso- and (~)-N,N’-dialkyl-1,2-bis(2,6-dichloro-4-hydroxypheny1) ethylenediamines (2) are described. They show high binding affinities in both diastereomeric forms but with a preference for the meso isomer, reaching a RBA value of 8.6 (meso-2b; 17@-estradiol=1 00). Both stereoisomers of 2b exhibit a strong inhibitory effect on the ...

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Item Type:Article
Date:November 1982
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
10.1021/jm00353a019DOI
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Martin Kaiser
Deposited On:17 May 2010 12:14
Last Modified:13 Mar 2014 13:28
Item ID:14970
Owner Only: item control page

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