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C-12-Substituted Indolo [2,1-a]isoquinolines as Estrogen Receptor Affinic Cytostatic Agents

Ambros, R. and Angerer, S. von and Wiegrebe, Wolfgang (1988) C-12-Substituted Indolo [2,1-a]isoquinolines as Estrogen Receptor Affinic Cytostatic Agents. Archiv der Pharmazie 321, pp. 743-747.

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Methoxysubstituted 5,6-dihydro-indolo[2,1-a]isoquinolines with a methyl (2b-f) or a formyl group at C-12 (4a-f) and 12,12-dimethylisoquinolinium salts (3b-f) were synthesized and tested for cytostatic activity in vitro. The tetramethoxy-indoloisoquinoline 4f was the most active derivative in the P 388 D1 leukemia cell line, whereas compounds with two methoxy groups (4a, 4b) were more potent ...


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Item Type:Article
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Wiegrebe
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Deposited On:07 Jul 2010 05:15
Last Modified:13 Mar 2014 13:47
Item ID:15696
Owner Only: item control page


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