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Selectivity of sterically fixed tryptamine and 5-methoxytryptamine derivatives for serotonin receptor subtypes, II: Structure-activity relationships and in vitro pharmacology of N-alkyl- and N,N-dialkyl-3- indolylbicyclo-[2.2.1]-heptane-2-amines

Elz, Sigurd and Zimmermann, H. and Rehse, K. (1993) Selectivity of sterically fixed tryptamine and 5-methoxytryptamine derivatives for serotonin receptor subtypes, II: Structure-activity relationships and in vitro pharmacology of N-alkyl- and N,N-dialkyl-3- indolylbicyclo-[2.2.1]-heptane-2-amines. Archiv der Pharmazie 326 (11), pp. 893-899.

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Abstract

Twenty-four norbornane analogues of tryptamine and 5-methoxytryptamine were investigated for affinity at 5-HT2 receptors of the rat tail artery and proved to be weak non-competitive antagonists of 5-HT. Compound 12 which displayed a marked depression of the concentration-effect curves, was examined for potential interaction with the allosteric binding site of the 5-HT2 receptor. The effects ...

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Item Type:Article
Date:1993
Additional information (public):Elz, S Zimmermann, H Rehse, K In Vitro Research Support, Non-U.S. Gov't Germany Archiv der Pharmazie Arch Pharm (Weinheim). 1993 Nov;326(11):893-9.
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
Identification Number:
ValueType
8274071Other
Keywords:5-Methoxytryptamine/analogs & derivatives/*chemical synthesis/pharmacology Animals Bicyclo Compounds/*chemical synthesis/pharmacology Female Guinea Pigs Indoles/*chemical synthesis/pharmacology Rats *Serotonin Antagonists Structure-Activity Relationship Tryptamines/*chemical synthesis/pharmacology
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Owner: Prof. Dr. Sigurd Elz
Deposited On:19 Oct 2010 12:27
Last Modified:19 Oct 2010 12:27
Item ID:17294
Owner Only: item control page
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