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Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

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Abstract

The diastereomeric 1-(fluoro/difluorophenyl)-2-phenylethylene-diamines (4-fluoro: erythro-1/threo-1; 2,4-difluoro: erythro-2/-threo-2; 2,6-difluoro: erythro-3/threo-3) and the diastereomeric 1-(4-fluorophenyl)-2-(3-hydroxyphenyl)ethylenediamines (erythro-4/-threo-4) were synthesized from appropriately substituted stilbenes by reaction with IN3 and subsequent LiAlH4 redn. Coordination of the ...

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Item Type:Article
Date:1995
Additional information (public):CAN 123:245214 78-7 Inorganic Chemicals and Reactions 168700-16-1P; 168700-17-2P; 168700-18-3P; 168700-19-4P; 168700-20-7P; 168700-21-8P; 168700-22-9P; 168700-23-0P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn. and antitumor activity of); 459-57-4 (4-Fluorobenzaldehyde); 603-35-0 (Triphenylphosphine); 824-98-6 (3-Methoxybenzyl chloride); 10025-99-7 (Potassium tetrachloroplatinate (K2PtCl4) Role: RCT (Reactant), RACT (Reactant or reagent) (prepn. of fluorophenyl- and difluorophenyl(phenyl)ethylenediamine deriv. diastereomers and their platinum complexes as antitumor agents); 18880-05-2P (3-Methoxybenzyltriphenylphosphonium chloride); 168700-04-7P; 168700-05-8P; 168700-06-9P; 168700-07-0P; 168700-08-1P; 168700-09-2P; 168700-10-5P; 168700-11-6P; 168700-12-7P; 168700-13-8P; 168700-14-9P; 168700-15-0P; 168700-26-3P; 168700-27-4P; 168700-28-5P (4-Fluoro-3'-methoxystilbene); 168700-29-6P; 168958-79-0P; 168958-80-3P; 168958-81-4P; 168958-82-5P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. of fluorophenyl- and difluorophenyl(phenyl)ethylenediamine deriv. diastereomers and their platinum complexes as antitumor agents); 168700-24-1P; 168700-25-2P; 168958-83-6P; 168958-84-7P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of fluorophenyl- and difluorophenyl(phenyl)ethylenediamine deriv. diastereomers and their platinum complexes as antitumor agents)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
1995:801120Other
Keywords:Neoplasm inhibitors Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (mammary gland, prepn. of fluorophenyl- and difluorophenyl(ph Mammary gland Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (neoplasm, inhibitors, prepn. of fluorophenyl- and difluorophenyl(p platinum fluorophenylethylenediamine deriv diastereomer prepn antitumor antitumor breast platinum fluorophenylethylenediamine deriv diastereomer
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:10 Nov 2010 11:55
Last Modified:10 Nov 2010 11:59
Item ID:17708
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