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[N-Ethyl- and [N,N'-Diethyl-1,2-bis(2,6-difluoro-3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II): Structure and Cytotoxic/Estrogenic Activity in Breast Cancer Cells

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (2005) [N-Ethyl- and [N,N'-Diethyl-1,2-bis(2,6-difluoro-3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II): Structure and Cytotoxic/Estrogenic Activity in Breast Cancer Cells. Journal of Medicinal Chemistry 48 (23), pp. 7132-7144.

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Abstract

N-Et and N,N'-diethyl derivs. (erythro- and threo-2-PtCl2; meso- and D,L-3-PtCl2) of [meso- and D,L-1,2-bis(2,6-difluoro-3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) (meso- and D,L-1-PtCl2) were synthesized and tested for cytotoxicity on the estrogen receptor-pos. (ER+) human MCF-7 breast cancer cell line. In this test, only D,L-1-PtCl2 and threo-2-PtCl2 showed strong cytotoxic ...

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Item Type:Article
Date:2005
Additional information (public):CAN 144:16568 1-6 Pharmacology 150390-77-5 Role: PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (cytotoxic/estrogenic activity in breast cancer cells of platinum(II) chloro bis(fluorohydroxyphenyl)ethylenediamine complexes); 150447-56-6 Role: PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (cytotoxic/estrogenic activity in breast cancer cells of platinum(II) chloro bis(fluoromethoxyphenyl)ethylenediamine complexes in comparison with analogous bis(fluorohydroxyphenyl)ethylenediamine complexes); 10025-99-7 (Dipotassium tetrachloroplatinate(2-); 149949-45-1; 149949-46-2 Role: RCT (Reactant), RACT (Reactant or reagent) (prepn. of platinum(II) chloro bis(fluorohydroxyphenyl)ethylenediamine complexes); 870526-03-7P; 870526-04-8P; 870526-05-9P; 870526-06-0P; 870526-07-1P; 870526-08-2P; 870526-09-3P; 870526-10-6P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. of platinum(II) chloro bis(fluorohydroxyphenyl)ethylenediamine complexes); 870526-01-5P; 870526-02-6P; 870623-25-9P; 870623-26-0P; 870623-27-1P; 870623-28-2P Role: PAC (Pharmacological activity), PRP (Properties), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. of platinum(II) chloro bis(fluorohydroxyphenyl)ethylenediamine complexes and their cytotoxic/estrogenic activity in breast cancer cells)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
2005:1122393Other
Keywords:Structure-activity relationship (antitumor prepn. of platinum(II) chloro bis(fluorohydroxyphenyl)ethylenediamine complexes and their cytotoxic/estrogenic activity in breast cancer cells) Antitumor agents Conformation Human Mammary gland (prepn. of platinum(II) chloro bis(fluorohydroxyphenyl)ethylenediamine complexes and their cytotoxic/estrogenic activity in breast cancer cells) Estrogen receptors Role: BSU (Biological study, unclassified), BIOL (Biological study) (prepn. of platinum(II) chloro bis(fluorohydroxyphenyl)ethylenediamine complexes and their cytotoxic/estrogenic activity in breast cancer cells) platinum chloro fluorohydroxyphenylethylenediamine prepn antitumor breast cancer
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:09 Nov 2010 14:12
Last Modified:09 Nov 2010 14:25
Item ID:17721
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