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Red-fluorescent argininamide-type NPY Y(1) receptor antagonists as pharmacological tools

Keller, Max and Erdmann, Daniela and Teng, Shangjun and Pop, Nathalie and Pluym, Nikola and Bernhardt, Günther and Buschauer, Armin (2011) Red-fluorescent argininamide-type NPY Y(1) receptor antagonists as pharmacological tools. Bioorganic & Medicinal Chemistry 19 (9), pp. 2859-2878.

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Abstract

Fluorescently labelled NPY Y1 receptor (Y1R) ligands were synthesized by connecting pyrylium and cyanine dyes with the argininamide-type Y1R antagonist core structure by linkers, covering a wide variety in length and chemical nature, attached to the guanidine group. The most promising fluorescent probes had Y1R affinities (radioligand binding) and antagonistic activities (calcium assay) in the ...

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Export bibliographical data

Item Type:Article
Date:16 March 2011
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
10.1016/j.bmc.2011.03.045DOI
21493077PubMed ID
Related URLs:
URLURL Type
http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TF8-52FVDD4-4-2K&_cdi=5220&_user=616165&_pii=S0968089611002264&_origin=gateway&_coverDate=05%2F01%2F2011&_sk=999809990&view=c&wchp=dGLbVlb-zSkzS&md5=44b465df6b744591d831624cd251c6c9&ie=/sdarticle.pPublisher
http://www.sciencedirect.com/science/MiamiMultiMediaURL/B6TF8-52FVDD4-4/B6TF8-52FVDD4-4-1/5220/html/S0968089611002264/f82d36d5aa7b84bc4647c190c530e20f/mmc1.pdfSupplementary Material
Keywords:NPY Y1 receptor; fluorescent ligands; Y1R binding; Y1R antagonism; argininamide derivatives; confocal microscopy; flow cytometry
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:24 Mar 2011 07:19
Last Modified:30 Apr 2011 14:46
Item ID:18611
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