Engelmann, B. and Schumacher, U. and Haen, Ekkehard
Epidermal growth factor binding sites on human erythrocytes in donors with different ABO blood groups.
American journal of hematology 39 (4), pp. 239-241.
Analysis of epidermal growth factor (125J-EGF) binding to human red cells revealed the presence of two classes of binding sites with apparent equilibrium dissociation constants (app.Kd) in the 10(-10)-10(-9) M and in the 10(-8) M range, respectively. The number of binding sites/cell ranged between 600 and 2,400 for the high-affinity binding site and between 7,200 and 23,000 for the low-affinity site. No differences were seen in the apparent Kd values for both types of binding sites between red cells obtained from donors with different ABO-blood groups. An increase in the number of high affinity EGF binding sites was observed in donors with blood group A1-erythrocytes as compared to red cells taken from donors with blood groups O and B.
|Institutions:|| Medicine > Lehrstuhl für Psychiatrie und Psychotherapie|
|ABO Blood-Group System/immunology||MESH|
|Epidermal Growth Factor/metabolism||MESH|
|Receptor, Epidermal Growth Factor/ultrastructure||MESH|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||18 Feb 2011 10:12|
|Last Modified:||21 Jul 2011 02:07|