Tarantola, M. and Schneider, D. and Sunnick, E. and Adam, H. and Pierrat, S. and Rosman, C. and Breus, V. and Soennichsen, C. and Basche, T. and Wegener, Joachim and Janshoff, A. (2009) Cytotoxicity of Metal and Semiconductor Nanoparticles Indicated by Cellular Micromotility. ACS Nano 3 (1), pp. 213-222.
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In the growing field of nanotechnology, there is an urgent need to sensitively determine the toxicity of nanoparticles since many technical and medical applications are based on controlled exposure to particles, that is, as contrast agents or for drug delivery. Before the in vivo implementation, in vitro cell experiments are required to achieve a detailed knowledge of toxicity and biodegradation as a function of the nanoparticles' physical and chemical properties. In this study, we show that the micromotility of animal cells as monitored by electrical cell-substrate impedance analysis (ECIS) is highly suitable to quantify in vitro cytotoxicity of semiconductor quantum dots and gold nanorods. The method is validated by conventional cytotoxicity testing and accompanied by fluorescence and dark-field microscopy to visualize changes in the cytoskeleton integrity and to determine the location of the particles within the cell.
|Date:||27 January 2009|
|Institutions:||Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Bioanalytik und Biosensorik (Prof. Joachim Wegener)|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||24 Mar 2011 07:18|
|Last Modified:||24 Mar 2011 07:18|