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Synthesis and characterization of DMAP-Modified NPY Y1 receptor antagonists as acyl-transfer catalysts

Weiss, Stefan ; Bernhardt, Günther ; Buschauer, Armin ; König, Burkhard



Zusammenfassung

Starting from the working hypothesis that specific chemical labelling may be an attractive approach to detect and study G protein-coupled receptors (GPCRs) we synthesized catalytically active antagonists of the neuropeptide Y1 receptor (Y1R). An argininamide-type Y1R antagonist scaffold was combined with a DMAP moiety via spacers of different length and chemical nature. These hybrid compounds ...

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