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Bacillus anthracis edema factor substrate specificity: evidence for new modes of action

Göttle, Martin and Dove, Stefan and Seifert, Roland (2012) Bacillus anthracis edema factor substrate specificity: evidence for new modes of action. Toxins 4 (7), pp. 505-535.

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Other URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407890/


Abstract

Since the isolation of Bacillus anthracis exotoxins in the 1960s, the detrimental activity of edema factor (EF) was considered as adenylyl cyclase activity only. Yet the catalytic site of EF was recently shown to accomplish cyclization of cytidine 5'-triphosphate, uridine 5'-triphosphate and inosine 5'-triphosphate, in addition to adenosine 5'-triphosphate. This review discusses the broad EF ...

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Item Type:Article
Date:2012
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
7546741PubMed ID
10.3390/toxins4070505DOI
Subjects:500 Science > 540 Chemistry & allied sciences
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Owner: Universitätsbibliothek Regensburg
Deposited On:15 Nov 2012 09:41
Last Modified:13 Mar 2014 19:25
Item ID:26716
Owner Only: item control page

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