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Effect of the ABCB1 modulators elacridar and tariquidar on the distribution of paclitaxel in nude mice.

Hubensack, Martina and Müller, Christine and Höcherl, Höcherl and Fellner, Stephan and Spruss, Thilo and Bernhardt, Günther and Buschauer, Armin (2008) Effect of the ABCB1 modulators elacridar and tariquidar on the distribution of paclitaxel in nude mice. Journal of Cancer Research and Clinical Oncology 134 (5), pp. 597-607.

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Other URL: http://www.springerlink.com/content/k1g77q8l48pm345g/


Abstract

PURPOSE: Previously, we studied the effect of co-administration of paclitaxel with the second generation ABCB1 (p-gp) modulator valspodar on the intracerebral growth of human U118-MG glioblastoma in nude mice. Valspodar significantly increased the brain levels of paclitaxel by inhibition of p-gp expressed at the blood brain barrier. Thus, the tumour burden was reduced by 90%, which was considered ...

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Item Type:Article
Date:2008
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
17932689PubMed ID
10.1007/s00432-007-0323-9DOI
Subjects:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:20 Feb 2008 15:51
Last Modified:13 Mar 2014 10:25
Item ID:3372
Owner Only: item control page

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